Newswise — Nearly one-third of cancer research published in high-impact journals disclosed a conflict of interest, according to a new study from researchers at the University of Michigan Comprehensive Cancer Center.
The most frequent type of conflict was industry funding of the study, which was seen in 17 percent of papers. Twelve percent of papers had a study author who was an industry employee. Randomized trials with reported conflicts of interest were more likely to have positive findings.
“Given the frequency we observed for conflicts of interest and the fact that conflicts were associated with study outcomes, I would suggest that merely disclosing conflicts is probably not enough. It’s becoming increasingly clear that we need to look more at how we can disentangle cancer research from industry ties,” says study author Reshma Jagsi, M.D., D.Phil., assistant professor of radiation oncology at the U-M Medical School.
The researchers looked at 1,534 cancer research studies published in prominent journals. Results of this current study appear online in the journal Cancer.
“A serious concern is individuals with conflicts of interest will either consciously or unconsciously be biased in their analyses. As researchers, we have an obligation to treat the data objectively and in an unbiased fashion. There may be some relationships that compromise a researcher’s ability to do that,” Jagsi says.
For example, she says, researchers might design industry-funded studies in a way that’s more likely to produce favorable results. They might also be more likely to publish positive outcomes than negative outcomes.
They found capsaicin, an ingredient of jalapeno peppers, triggers cancer cell death by attacking mitochondria - the cells' energy-generating boiler rooms.
The research raises the possibility that other cancer drugs could be developed to target mitochondria.
The Nottingham University study features in Biochemical and Biophysical Research Communications.
The study showed that the family of molecules to which capsaicin belongs, the vanilloids, bind to proteins in the cancer cell mitochondria to trigger apoptosis, or cell death, without harming surrounding healthy cells.
 Monthly injections of testosterone lowered sperm count |
A male contraceptive jab could be as effective at preventing pregnancies as the female pill or condoms, work shows.
The monthly testosterone injection works by temporarily blocking sperm production and could revolutionise birth control, experts believe.
In trials in China only one man in 100 fathered a child while on the injections, the Journal of Clinical Endocrinology & Metabolism reports.
Six months after stopping the jabs the men's sperm counts returned to normal.
Family planning campaigners welcomed the news and said they hoped an injection would give couples more choice and enable men to take a greater share of the responsibility for contraception.
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